What is Rejuran Healer?
Rejuran Healer is the core product of the Rejuran range, a polynucleotide injectable used with the aim of supporting overall facial skin quality.
The product contains polynucleotides obtained from purified salmon DNA fragments. These long nucleotide chains form a gel-like consistency and are injected into the skin at many small points. The aim is to support the skin's own repair processes and moisture balance. The product does not change your genetic make-up or become part of your cells' DNA. Developed in South Korea, it is one of the better-known names internationally when people search for salmon DNA.
Compared with the other products in the range, Rejuran Healer is intended for broader areas of the face. Rejuran i for the thin skin around the eyes and Rejuran S for atrophic scar areas are separate options. The product's legal status and traceability in Türkiye are checked before treatment, and you may ask to see the packaging and batch details. The choice of product is made by the physician according to the area and your skin.
Which skin concerns does Rejuran Healer aim to address, and what does it not do?
It aims to support dull, dehydrated-looking skin, fine lines, uneven texture and loss of elasticity; it does not provide volume or lift.
Rejuran Healer is usually considered with the aim of making skin texture look more even, hydrated and fresh. Softening of fine lines and support for the appearance of enlarged pores may also be among the goals. Change is gradual and is followed over the course of sessions. The outcome varies with age, skin type, sun damage and lifestyle, so expectations are discussed realistically at the consultation based on your skin's starting point.
For volume loss in areas such as the cheeks or temples, marked sagging, deep wrinkles or lines caused by muscle movement, Rejuran Healer alone may not be enough. In those situations fillers, botulinum toxin, biostimulators or energy-based devices may be considered. The physician explains which method might address which concern. Where appropriate, more than one approach can be sequenced within the same plan at suitable intervals.
How is it performed, and how many sessions are needed?
After a topical anaesthetic cream, the product is placed with a fine needle in small points across the face; a common plan is three to four sessions, two to four weeks apart.
The skin is cleansed and a topical anaesthetic cream is usually applied for a while. The product is then placed with a fine needle as many small injections, or with a cannula in some areas. You may feel stinging and pressure; sensitivity varies from person to person. Excluding preparation, the procedure often takes 20–40 minutes. Afterwards the skin is cleansed and, after a short period of observation, you can usually resume normal activities.
A common plan is three to four sessions, two to four weeks apart, but the number depends on your skin and goals. How long the effect lasts varies between individuals, and maintenance timing is agreed at follow-up. If Rejuran Healer is to be combined with other treatments, the order and intervals are set by the physician. If you have an important event or a flight home, plan treatment a few days beforehand.
Who may not be suitable for Rejuran Healer?
It is generally not recommended, or is postponed, in cases of fish or salmon allergy, pregnancy, breastfeeding or active infection at the treatment site.
Because the product is salmon-derived, your allergy history is asked about in detail. There is insufficient safety data for pregnancy and breastfeeding, so treatment is deferred until afterwards. If you have a cold sore, an acne flare or another skin infection, the area is allowed to heal first. Known hypersensitivity to any ingredient is also a reason not to proceed, and alternative approaches are then discussed.
Active autoimmune disease, bleeding disorders, blood-thinning medication and a tendency to keloid scarring need further assessment. Recent laser, peel or filler treatments may also affect timing. Sharing your medicines and skincare products at the consultation helps make the plan safer. The decision on suitability is made by the physician once all of this information has been reviewed in person.
What should I watch for afterwards, and what are the possible side effects?
Redness, mild swelling, bruising and small bumps at the injection points can occur; these usually settle within a few days.
Small raised bumps (papules) at the injection points are common and usually flatten within a few days. Tenderness, mild swelling and bruising may also appear; bruising can be more noticeable if you take blood thinners. Rarely, an allergic reaction, infection or prolonged redness can develop. If you notice increasing pain, marked swelling, fever or widespread itching, contact your physician without delay.
You are advised not to wear make-up on the first day and not to press on the bumps. Avoiding saunas, steam rooms, strenuous exercise and alcohol for a few days, using sunscreen and cleansing with gentle products are generally recommended. When you can return to retinoids or acid-based products is explained individually. At follow-up your skin's response is reviewed and the next session is planned.
Frequently asked questions
Which areas of the face is Rejuran Healer used on?
It is usually applied across the face. Other areas such as the neck may be planned depending on the physician's assessment and the product's instructions for use. Rejuran i is a separate option for the eye area.
When does Rejuran Healer start to show an effect?
Change is usually gradual and is assessed over the course of sessions. Response differs from person to person.
Is Rejuran Healer the same as filler?
No. Rejuran Healer aims to support skin quality and does not add volume. Volume loss may need a different approach, such as hyaluronic acid filler.
Can I go back to work after treatment?
Most people return to daily activities the same day. Redness and small bumps may be visible for a few days, so it is sensible to plan around important events.
How long before my wedding should I start Rejuran Healer?
Starting Rejuran Healer about 2–3 months before your wedding makes planning easier, because its effect is assessed gradually over a course of sessions. The last session is usually advised at least 1–2 weeks before the day, so redness, bruising and bumps can settle. A first treatment just days before is not advised, as your skin's response is still unknown.
When can I go back to retinol after Rejuran Healer?
Most people can return to retinol, prescription retinoids and acid products such as AHAs and BHAs once redness and bumps from Rejuran Healer have fully settled, usually within a few days to a week. Because these products can irritate recovering skin, a gentle cleanser, moisturiser and sunscreen are enough at first. If you use a prescription retinoid, confirm timing with your physician.
Can Rejuran Healer be combined with laser or other device treatments?
Yes, Rejuran Healer can be part of the same plan as laser, radiofrequency or ultrasound treatments. Some combinations are done on the same day, others a few days to a few weeks apart so the skin can recover, depending on the device and your skin's reaction. When done on the same day, the device treatment usually comes first, followed by the Rejuran Healer injections.
Does Rejuran Healer shrink pores?
Rejuran Healer is not a pore-shrinking treatment, but as skin texture and hydration are supported, enlarged pores may look less noticeable in some people. Oil production, acne and sun damage continue to affect how pores look. Where pores are a major concern, regular skincare, peels or device treatments may be considered alongside Rejuran Healer.
Sources (2)
- Clin Cosmet Investig Dermatol: Expert Perspectives: Evidence-Based Applications of Polynucleotides (PNs) in Aesthetic Medicine and Dermatology (2026)
- Plast Reconstr Surg Glob Open: A Prospective Split-face Trial Evaluating Skin Recovery and Enhancement with Polynucleotide (Rejuran) Following Fractional Needle Radiofrequency Treatment (2026)
This content is for general information and does not replace a personal medical assessment.